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Content of the Research Project

This research project will involve the collaboration of scientists who specialize in germ cells and epigenetics research. The project is divided into three areas: (1) spermatogenesis, (2) oogenesis and fertilization, and (3) epigenome analysis. Research by the groups studying these three areas will focus on the following two topics:

  • Understanding the molecular mechanism of how the epigenetic network is formed and maintained during germ cell development.
  • Developing new methods to correct the deregulated epigenome program in germ cells and embryos.

Expected Research Achievements and Scientific Significance

Our project will clarify the reprogramming mechanism of germ cells at the molecular level, which will deepen our knowledge of the difference between germ and somatic cells. In addition, the development of new methods for epigenetic manipulation will have important implications for preventing human diseases and improving health.


Head investigator:
Prof. Takashi Shinohara

Department of Molecular Genetics, Graduate School of Medicine, Kyoto University.

Yoshida-Konoe-cho,Sakyo-ku, Kyoto 606-8501, Japan

Prof. Masahito Ikawa

Animal Resource Center for Infectious Diseases, Research Institute for Microbial Diseases, Osaka University.

Yamadaoka 3-1, Suita, Osaka 565-0871, Japan