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2017

  1. Roles of MIWI, MILI, and PLD6 in small RNA regulation in mouse growing oocytes.
    Kabayama, Y., Toh, H., Katanaya, A., Sakurai, T., Chuma, S., Kuramochi-Miyagawa, S., Saga, Y., Nakano, T. & Sasaki, H.
    Nucleic Acids Res. 2017 Jan 23. [Epub ahead of print]

  2. Testis-Specific Histone Variant H3t Gene Is Essential for Entry into Spermatogenesis.
    Ueda J, Harada A, Urahama T, Machida S, Maehara K, Hada M, Makino Y, Nogami J, Horikoshi N, Osakabe A, Taguchi H, Tanaka H, Tachiwana H, Yao T, Yamada M, Iwamoto T, Isotani A, Ikawa M, Tachibana T, Okada Y, Kimura H, Ohkawa Y, Kurumizaka H, Yamagata K.
    Cell Rep. 2017 Jan 17;18(3):593-600.

  3. Software updates in the Illumina HiSeq platform affect whole-genome bisulfite sequencing.
    Toh H, Shirane K, Miura F, Kubo N, Ichiyanagi K, Hayashi K, Saitou M, Suyama M, Ito T, Sasaki H.
    BMC Genomics. 2017 Jan 5;18(1):31.


2016

  1. In Vitro Derivation and Propagation of Spermatogonial Stem Cell Activity from Mouse Pluripotent Stem Cells.
    Ishikura Y, Yabuta Y, Ohta H, Hayashi K, Nakamura T, Okamoto I, Yamamoto T, Kurimoto K, Shirane K, Sasaki H, Saitou M.
    Cell Rep. 2016 Dec 6;17(10):2789-2804.

  2. PRDM14 Drives OCT3/4 Recruitment via Active Demethylation in the Transition from Primed to Naive Pluripotency.
    Okashita N, Suwa Y, Nishimura O, Sakashita N, Kadota M, Nagamatsu G, Kawaguchi M, Kashida H, Nakajima A, Tachibana M, Seki Y.
    Stem Cell Reports.2016 Dec 13;7(6):1072-1086.

  3. Global Landscape and Regulatory Principles of DNA Methylation Reprogramming for Germ Cell Specification by Mouse Pluripotent Stem Cells.
    Shirane K, Kurimoto K, Yabuta Y, Yamaji M, Satoh J, Ito S, Watanabe A, Hayashi K, Saitou M, Sasaki H.
    Dev Cell. 2016 Oct 10;39(1):87-103.

  4. Sexual Fate Change of XX Germ Cells Caused by the Deletion of SMAD4 and STRA8 Independent of Somatic Sex Reprogramming.
    Wu Q, Fukuda K, Kato Y, Zhou Z, Deng CX, Saga Y.
    PLoS Biol. 2016 Sep 8;14(9):e1002553.

  5. The Luteinizing Hormone-Testosterone Pathway Regulates Mouse Spermatogonial Stem Cell Self-Renewal by Suppressing WNT5A Expression in Sertoli Cells.
    Tanaka T, Kanatsu-Shinohara M, Lei Z, Rao CV, Shinohara T.
    Stem Cell Reports. 2016 Aug 9;7(2):279-91.

  6. Nonrandom Germline Transmission of Mouse Spermatogonial Stem Cells.
    Kanatsu-Shinohara M, Naoki H, Shinohara T.
    Dev Cell. 2016 Aug 8;38(3):248-61.

  7. Piwi Modulates Chromatin Accessibility by Regulating Multiple Factors Including Histone H1 to Repress Transposons.
    Iwasaki YW, Murano K, Ishizu H, Shibuya A, Iyoda Y, Siomi MC, Siomi H, Saito K.
    Mol Cell.2016 Aug 4;63(3):408-19.

  8. Structural and functional insights into IZUMO1 recognition by JUNO in mammalian fertilization.
    Kato K, Satouh Y, Nishimasu H, Kurabayashi A, Morita J, Fujihara Y, Oji A, Ishitani R, Ikawa M, Nureki O.
    Nat Commun. 2016 Jul 15;7:12198.

  9. Genome engineering uncovers 54 evolutionarily conserved and testis-enriched genes that are not required for male fertility in mice.
    Miyata H, Castaneda JM, Fujihara Y, Yu Z, Archambeault DR, Isotani A, Kiyozumi D, Kriseman ML, Mashiko D, Matsumura T, Matzuk RM, Mori M, Noda T, Oji A, Okabe M, Prunskaite-Hyyrylainen R, Ramirez-Solis R, Satouh Y, Zhang Q, Ikawa M, Matzuk MM.
    Proc Natl Acad Sci U S A. 2016 Jul 12;113(28):7704-10.

  10. A potential role of endoplasmic reticulum stress in development of ovarian hyperstimulation syndrome.
    Takahashi N, Harada M, Hirota Y, Zhao L, Yoshino O, Urata Y, Izumi G, Takamura M, Hirata T, Koga K, Wada-Hiraike O, Fujii T, Osuga Y.
    Mol Cell Endocrinol. 2016 Jun 15;428:161-9.

  11. Effects of 1,25-dihydroxy vitamin D3 on endometriosis.
    Miyashita M, Koga K, Izumi G, Sue F, Makabe T, Taguchi A, Nagai M, Urata Y, Takamura M, Harada M, Hirata T, Hirota Y, Wada-Hiraike O, Fujii T, Osuga Y.
    J Clin Endocrinol Metab. 2016 Jun;101(6):2371-9.

  12. Inheritance of a Nuclear PIWI from Pluripotent Stem Cells by Somatic Descendants Ensures Differentiation by Silencing Transposons in Planarian.
    Shibata N, Kashima M, Ishiko T, Nishimura O, Rouhana L, Misaki K, Yonemura S, Saito K, Siomi H, Siomi MC, Agata K.
    Dev Cell. 2016 May 9;37(3):226-37.

  13. The Mg2+ transporter CNNM4 regulates sperm Ca2+ homeostasis and it is essential for reproduction.
    Yamazaki D, Miyata H, Funato Y, Fujihara Y, Ikawa M, Miki H.
    J Cell Sci. 2016 May 1;129(9):1940-9.

  14. Resveratrol Enhances Apoptosis in Endometriotic Stromal Cells.
    Taguchi A, Koga K, Kawana K, Makabe T, Sue F, Miyashita M, Yoshida M, Urata Y, Izumi G, Takamura M, Harada M, Hirata T, Hirota Y, Wada-Hiraike O, Fujii T, Osuga Y.
    Am J Reprod Immunol. 2016 Apr;75(4):486-92.

  15. Behavior of Mouse Spermatozoa in the Female Reproductive Tract from Soon after Mating to the Beginning of Fertilization.
    Muro Y, Hasuwa H, Isotani A, Miyata H, Yamagata K, Ikawa M, Yanagimachi R, Okabe M.
    Biol Reprod. 2016 Apr;94(4):80.

  16. Fertilization defects in sperm from Cysteine-rich secretory protein 2 (Crisp2) knockout mice: Implications for fertility disorders.
    Brukman NG, Miyata H, Torres P, Lombardo D, Caramelo JJ, Ikawa M, Da Ros VG, Cuasnicú PS.
    Mol Hum Reprod. 2016 Apr;22(4):240-51.

  17. Dazl is a target RNA suppressed by mammalian NANOS2 in sexually differentiating male germ cells.
    Kato Y, Katsuki T, Kokubo H, Masuda A, Saga Y.
    Nat Commun. 2016 Apr 13;7:11272.

  18. Loss of MAX results in meiotic entry in mouse embryonic and germline stem cells
    Suzuki A, Hirasaki M, Hishida T, Wu J, Okamura D, Ueda A, Nishimoto M, Nakachi Y, Mizuno Y, Okazaki Y, Matsui Y, Izpisua Belmonte JC, Okuda A.
    Nat Commun. 2016 Mar 30;7:11056.

  19. De novo DNA methylation drives 5hmC accumulation in mouse zygotes.
    Amouroux R, Nashun B, Shirane K, Nakagawa S, Hill PW, D'Souza Z, Nakayama M, Matsuda M, Turp A, Ndjetehe E, Encheva V, Kudo NR, Koseki H, Sasaki H, Hajkova P.
    Nat Cell Biol. 2016 Feb;18(2):225-33.

  20. Combined overexpression of Jarid2, Prdm14, Esrrb, and Sall4A dramatically improves efficiency and kinetics of reporgramming to induced pluripotent stem cells.
    Iseki H, Nakachi Y, Hishida T, Yamashita-Sugawara Y, Hirasaki M, Ueda A, Tanimoto Y, Iijima S, Yagami K, Takahashi S, Okuda A, Okazaki Y.
    Stem Cells 2016 Feb;34(2):322-33.

  21. Characterization of gene expression in mouse embryos at the 1-cell stage.
    Yamamoto, R., Abe, K., Suzuki, Y., Suzuki, M.G, Aoki, F.
    J. Reprod. Dev. 2016 Feb 20; 62: 87-92.

  22. Long-term ex vivo maintenance of testis tissues producing fertile sperm in a microfluidic device.
    Komeya M, Kimura H, Nakamura H, Yokonishi T, Sato T, Kojima K, Hayashi K, Katagiri K, Yamanaka H, Sanjo H, Yao M, Kamimura S, Inoue K, Ogonuki N, Ogura A, Fujii T, Ogawa T.
    Sci Rep. 2016 Feb 19;6:21472.

  23. Selection of accurate reference genes in mouse trophoblast stem cells for reverse transcription-quantitative polymerase chain reaction.
    Motomura K, Inoue K, Ogura A.
    J Reprod Dev. 2016 Jun 17;62(3):311-5.

  24. Analysis of chromatin structure in mouse preimplantation embryos by fluorescent recovery after photobleaching.
    Ooga M, Fulka H, Hashimoto S, Suzuki M.G, Aoki F.
    Epigenetics 2016 Jan 2; 11(1): 85-94.

  25. Dead end1 is an essential partner of NANOS2 for selective binding of target RNAs in male germ cell development.
    Suzuki A, Niimi Y, Shinmyozu K, Zhou Z, Kiso M, Saga Y.
    EMBO Rep. 2016 Jan;17(1):37-46.

  26. Lentiviral Vector Mediated Complementation Restored Fetal Viability but Not Placental hyperplasia in Plac1-Deficient Mice.
    Muto M, Fujihara Y, Tobita T, Kiyozumi D, Ikawa M.
    Biol Reprod. 2016 Jan;94(1):6.

  27. Enrichment of mouse spermatogonial stem cells by the stem cell dye CDy1.
    Kanatsu-Shinohara M, Morimoto H, Shinohara T.
    Biol. Reprod. 2016 Jan; 94(1):13.

  28. High-yield superovulation in adult mice by anti-inhibin serum treatment combined with estrous cycle synchronization.
    Hasegawa A, Mochida K, Inoue H, Noda Y, Endo T, Watanabe G, Ogura A. 
    Biol Reprod. 2016 Jan;94(1):21.


2015

  1. Pluripotent cell derivation from male germline cells by suppression of Dmrt1 and Trp53.
    Tanaka T, Kanatsu-Shinohara M, Hirose M, Ogura A, Shinohara T.
    J. Reprod. Dev. 2015; 61(5):473-84.

  2. The CDKN1B-RB1-E2F1 pathway protects mouse spermatogonial stem cells from genomic damage.
    Tanaka T, Kanatsu-Shinohara M, Shinohara T.
    J. Reprod. Dev. 2015; 61(4):305-16.

  3. Simultaneous Detection and Evaluation of Four Subsets of CD4+ T Lymphocyte in Lesions and Peripheral Blood in Endometriosis.
    Takamura M, Koga K, Izumi G, Hirata T, Harada M, Hirota Y, Hiraike O, Fujii T, Osuga Y.
    Am J Reprod Immunol. 2015 Dec;74(6):480-6.

  4. Naïve-like conversion enhances the difference in innate in vitro differentiation capacity between rabbit ES cells and iPS cells.
    Honsho K, Hirose M, Hatori, Yasmin L, Izu H, Matoba S, Togayachi S, Miyoshi H, Sankai T, Ogura A, Honda A.
    J Reprod Dev. 2015;61(1):13-9.

  5. The oncogenic role of GASC1 in chemically induced mouse skin cancer.
    Ozaki Y, Fujiwara K, Ikeda M, Ozaki T, Terui T, Soma M, Inazawa J, Nagase H.
    Mammalian Genome. 2015 Dec; 26(11-12):591-7.

  6. In quest of genomic treasure.
    Inoue K, Ogura A.
    J Reprod Dev. 2015;61(6):489-93.

  7. Global DNA hypomethylation coupled to cellular transformation and metastatic ability.
    Funaki S, Nakamura T, Nakatani T, Umehara H, Nakashima H, Okumura M, Oboki K, Matsumoto K, Saito H, Nakano T.
    FEBS lett. 2015 Dec 21;589: 4053-60.

  8. The Constrained Maximal Expression Level Owing to Haploidy Shapes Gene Content on the Mammalian X Chromosome.
    Hurst LD, Ghanbarian AT, Forrest AR; FANTOM consortium, Huminiecki L.
    PLoS Biol. 2015 Dec 18;13(12):e1002315.

  9. Application of Gene Expression Trajectories Initiated from ErbB Receptor Activation Highlights the Dynamics of Divergent Promoter Usage.
    Carbajo D, Magi S, Itoh M, Kawaji H, Lassmann T, Arner E, Forrest AR, Carninci P, Hayashizaki Y, Daub CO; FANTOM consortium, Okada-Hatakeyama M, Mar JC.
    PLoS One. 2015 Dec 14;10(12):e0144176.

  10. A role of TMEM16E carrying a scrambling domain in sperm motility.
    Gyobu S, Miyata H, Ikawa M, Yamazaki D, Takeshima H, Suzuki J, Nagata S.
    Mol Cell Biol. 2015 Dec 14;36(4):645-59.

  11. Elf5-centered transcription factor hub controls trophoblast stem cell self-renewal and differentiation through stoichiometry-sensitive shifts in target gene networks.
    Latos PA, Sienerth AR, Murray A, Senner CE, Muto M, Ikawa M, Oxley D, Burge S, Cox BJ, Hemberger M.
    Genes Dev. 2015 Dec 1;29(23):2435-48.

  12. De novo DNA methylation through the 5'-segment of the H19 ICR maintains its imprint during early embryogenesis.
    Matsuzaki H, Okamura E, Takahashi T, Ushiki A, Nakamura T, Nakano T, Hata K, Fukamizu A, Tanimoto K.
    Development. 2015 Nov 15;142(22):3833-44.

  13. Histone chaperone CAF-1 mediates repressive histone modifications to protect preimplantation mouse embryos from endogenous retrotransposons.
    Hatanaka Y, Inoue K, Oikawa M, Kamimura S, Ogonuki N, Kodama EN, Ohkawa Y, Tsukada Y, Ogura A.
    Proc Natl Acad Sci U S A. 2015 Nov 24;112(47):14641-6.

  14. Sperm Postacrosomal WW Domain-Binding Protein Is Not Required for Mouse Egg Activation.
    Satouh Y, Nozawa K, Ikawa M.
    Biol Reprod. 2015 Oct;93(4):94.

  15. Evidence of the activation of unfolded protein response in granulosa and cumulus cells during follicular growth and maturation.
    Harada M, Nose E, Takahashi N, Hirota Y, Hirata T, Yoshino O, Koga K, Fujii T, Osuga Y.
    Gynecol Endocrinol. 2015 Oct;31(10):783-7.

  16. Maternal TET3 is dispensable for embryonic development but is required for neonatal growth.
    Tsukada Y, Akiyama T, Nakayama KI.
    Sci Rep. 2015 Oct 28;5:15876.

  17. Sperm calcineurin inhibition prevents mouse fertility with implications for male contraceptive.
    Miyata H, Satouh Y, Mashiko D, Muto M, Nozawa K, Shiba K, Fujihara Y, Isotani A, Inaba K, Ikawa M.
    Science. 2015 Oct 23;350(6259):442-5.

  18. CRISPR/Cas9-Mediated Rapid Generation of Multiple Mouse Lines Identified Ccdc63 as Essential for Spermiogenesis.
    Young SA, Miyata H, Satouh Y, Kato H, Nozawa K, Isotani A, Aitken RJ, Baker MA, Ikawa M.
    Int J Mol Sci. 2015 Oct 16;16(10):24732-24750.

  19. Silencing of RUNX2 enhances gemcitabine sensitivity of p53-deficient human pancreatic cancer AsPC-1 cells through the stimulation of TAp63-mediated cell death.
    Ozaki T, Sugimoto H, Nakamura M, Yoda H, Hiraoka K, Shinohara K, Sang M, Fujiwara K, Shimozato O and Nagase H.
    Cell Death Dis. 2015 Oct 15;6:e1914.

  20. Selective Targeting of the KRAS Codon 12 Mutation Sequence by Pyrrole-Imidazole Polyamide seco-CBI Conjugates.
    Taylor RD, Chandran A, Kashiwazaki G, Hashiya K, Bando T, Nagase H and Sugiyama H.
    Chemistry. 2015 Oct 12;21(42):14996-5003.

  21. Stella controls chromocenter formation through regulation of Daxx expression in 2-cell embryos.
    Arakawa T, Nakatani T, Oda M, Kimura Y, Sekita Y, Kimura T, Nakamura T, Nakano T.
    Biochem Biophys Res Commun. 2015 Oct 9;466(1):60-5.

  22. PRDM14 maintains pluripotency of embryonic stem cells through TET-mediated active DNA demethylation.
    Okashita N, Sakashita N, Ito K, Mitsuya A, Suwa Y, Seki Y.
    Biochem. Biophys. Res. Commun., 2015 Oct 9; 466(1):138-45.

  23. A Niche for GFRα1-positive spermatogonia in the Terminal Segments of the Seminiferous Tubules in Hamster Testes.
    Aiyama Y, Tsunekawa N, Kishi K, Kawasumi M, Suzuki H, Kanai-Azuma M, Kurohmaru M, Kanai Y.
    Stem Cells. 2015 Sep;33(9):2811-24.

  24. Calreticulin is required for development of the cumulus oocyte complex and female fertility.
    Tokuhiro K, Satouh Y, Nozawa K, Isotani A, Fujihara Y, Hirashima Y, Matsumura H, Takumi K, Miyano T, Okabe M, Benham AM, Ikawa M.
    Sci Rep. 2015 Sep 21;5:14254.

  25. Functional analysis of sex-determination genes by gene silencing with LNA-DNA gapmers in the silkworm, Bombyx mori.
    Sakai H, Sakaguchi H, Aoki F, Suzuki M.G.
    Mech. Dev. 2015 Aug; 137: 45-52.

  26. Functional analysis of sex-determination genes by gene silencing with LNA-DNA gapmers in the silkworm, Bombyx mori.
    Sakai H, Sakaguchi H, Aoki F, Suzuki MG.
    Mech Dev. 2015 Aug;137:45-52.

  27. DNA methylation and gene expression dynamics during spermatogonial stem cell differentiation in the early postnatal mouse testis.
    Kubo N, Toh H, Shirane K, Shirakawa T, Kobayashi H, Sato T, Sone H, Sato Y, Tomizawa S, Tsurusaki Y, Shibata H, Saitsu H, Suzuki Y, Matsumoto N, Suyama M, Kono T, Ohbo K, Sasaki H.
    BMC Genomics. 2015 Aug 20;16(1):624.

  28. Human Dynactin-Associated Protein Transforms NIH3T3 Cells to Generate Highly Vascularized Tumors with Weak Cell-Cell Interaction.
    Kunoh T, Wang W, Kobayashi H, Matsuzaki D, Togo Y, Tokuyama M, Hosoi M, Koseki K, Wada S, Nagai N, Nakamura T, Nomura S, Hasegawa M, Sasaki R, Mizukami T.
    PLoS One. 2015 Aug 18;10(8)

  29. Reply to Shoji and Katsuma.
    Kuramochi-Miyagawa S, Nakano T.
    Curr Biol. 2015 Aug 17;25(16):R710.

  30. Double strand break repair by capture of retrotransposon sequences and reverse-transcribed spliced mRNA sequences in mouse zygotes.
    Ono R, Ishii M, Fujihara Y, Kitazawa M, Usami T, Kaneko-Ishino T, Kanno J, Ikawa M, Ishino F.
    Sci Rep. 2015 Jul 28;5:12281.

  31. Genome Editing in Mouse Spermatogonial Stem Cell Lines Using TALEN and Double-Nicking CRISPR/Cas9.
    Sato T, Sakuma T, Yokonishi T, Katagiri K, Kamimura S, Ogonuki N, Ogura A, Yamamoto T, Ogawa T.
    Stem Cell Reports. 2015 Jul 14;5(1):75-82.

  32. RNA Binding Protein Nanos2 Organizes Post-transcriptional Buffering System to Retain Primitive State of Mouse Spermatogonial Stem Cells.
    Zhou Z, Shirakawa T, Ohbo K, Sada A, Wu Q, Hasegawa K, Saba R, Saga Y.
    Dev Cell. 2015 Jul 6;34(1):96-107.

  33. Pyrrole-imidazole polyamide-mediated silencing of KCNQ1OT1 expression induces cell death in Wilms' tumor cells.
    Yoshizawa S, Fujiwara K, Sugito K, Uekusa S, Kawashima H, Hoshi R, Watanabe Y, Hirano T, Furuya T, Masuko T, Ueno T, Fukuda N, Soma M, Ozaki T, Koshinaga T, Nagase H.
    Int J Oncol. 2015 Jul;47(1):115-21.

  34. H3K9MTase G9a is essential for the differentiation and growth of tenocytes in vitro.
    Wada S, Ideno H, Shimada A, Kamiunten T, Nakamura Y, Nakashima K, Kimura H, Shinkai Y, Tachibana M and Nifuji A.
    Histochem Cell Biol. 2015 Jul;144(1):13-20.

  35. Drospirenone induces decidualization in human eutopic endometrial stromal cells and reduces DNA synthesis of human endometriotic stromal cells.
    Miyashita M, Koga K, Izumi G, Makabe T, Hasegawa A, Hirota Y, Hirata T, Harada M, Fujii T, Osuga Y.
    Fertil Steril. 2015 Jul;104(1):217-24.e2.

  36. Lhx8 regulates primordial follicle activation and postnatal folliculogenesis.
    Ren Y, Suzuki H, Jagarlamudi K, Golnoski K, McGuire M, Lopes R, Pachnis V, Rajkovic A.
    BMC Biol. 2015 Jun 16;13(1):39.

  37. Muscle Segment Homeobox Genes Direct Embryonic Diapause by Limiting Inflammation in the Uterus.
    Cha J, Burnum-Johnson KE, Bartos A, Li Y, Baker ES, Tilton SC, Webb-Robertson BJ, Piehowski PD, Monroe ME, Jegga AG, Murata S, Hirota Y, Dey SK.
    J Biol Chem. 2015 Jun 12;290(24):15337-49.

  38. The first murine zygotic transcription is promiscuous and uncoupled from splicing and 3' processing.
    Abe K, Yamamoto R, Franke V, Cao M, Suzuki Y, Suzuki MG, Vlahovicek K, Svoboda P, Schultz RM, Aoki F.
    EMBO J. 2015 Jun 3;34(11):1523-37.

  39. Identification of a transformer homolog in the acorn worm, Saccoglossus kowalevskii, and analysis of its activity in insect cells.
    Suzuki M.G, Tochigi M, Sakaguchi H, Aoki F, Miyamoto N.
    Dev. Genes. Evol. 2015 Jun; 225: 161-169.

  40. Involvement of histone H2B mono-ubiquitination in the regulation of mouse preimplantation development.
    Ooga M, Suzuki M.G, Aoki F.
    J. Reprod. Dev. 2015 Jun; 61, 179-184.

  41. Cyclic stretch augments production of neutrophil chemokines, matrix metalloproteinases, and activin A in human endometrial stromal cells.
    Izumi G, Koga K, Nagai M, Urata Y, Takamura M, Harada M, Hirata T, Hirota Y, Ogawa K, Inoue S, Fujii T, Osuga Y.
    Am J Reprod Immunol. 2015 Jun;73(6):501-6.

  42. ROS-generating oxidase Nox3 regulates the self-renewal of mouse spermatogonial stem cells.
    Morimoto H, Kanatsu-Shinohara M, Shinohara T.
    Biol. Reprod. 2015 Jun; 92(6):147.

  43. Development of a general-purpose method for cell purification using Cre/loxP-mediated recombination.
    Kuroki S, Akiyoshi M, Ideguchi K, Kitano S, Miyachi H, Hirose M, Mise N, Abe K, Ogura A, Tachibana M.
    Genesis. 2015 Jun;53(6):387-93.

  44. Trichostatin A specifically improves the aberrant expression of transcription factor genes in embryos produced by somatic cell nuclear transfer.
    Inoue K, Oikawa M, Kamimura S, Ogonuki N, Nakamura T, Nakano T, Abe K, Ogura A.
    Sci Rep. 2015 May 14;5:10127.

  45. Preclinical Study of Novel Gene Silencer Pyrrole-Imidazole Polyamide Targeting Human TGF-β1 Promoter for Hypertrophic Scars in a Common Marmoset Primate Model.
    Igarashi J, Fukuda N, Inoue T, Nakai S, Saito K, Fujiwara K, Matsuda H, Ueno T, Matsumoto Y, Watanabe T, Nagase H, Bando T, Sugiyama H, Itoh T, Soma M.
    PLoS One. 2015 May 4;10(5):e0125295.

  46. Impaired active DNA demethylation in zygotes generated by round spermatid injection.
    Kurotaki YK, Hatanaka Y, Kamimura S, Oikawa M, Inoue H, Ogonuki N, Inoue K, Ogura A.
    Hum Reprod. 2015 May;30(5):1178-87.

  47. Stella preserves maternal chromosome integrity by inhibiting 5hmC-induced γH2AX accumulation.
    Nakatani T, Yamagata K, Kimura T, Oda M, Nakashima H, Hori M, Sekita Y, Arakawa T, Nakamura T, Nakano T.
    EMBO Rep. 2015 May;16(5):582-9.

  48. Inhibition of KRAS codon 12 mutants using a novel DNA-alkylating pyrrole-imidazole polyamide conjugate.
    Hiraoka K, Inoue T, Taylor RD, Watanabe T, Koshikawa N, Yoda H, Shinohara K, Takatori A, Sugimoto H, Maru Y, Denda T, Fujiwara K, Balmain A, Ozaki T, Bando T, Sugiyama H, Nagase H.
    Nat Commun. 2015 Apr 27;6:6706.

  49. A novel transcriptional factor nkapl is a germ cell-specific suppressor of notch signaling and is indispensable for spermatogenesis.
    Okuda H, Kiuchi H, Takao T, Miyagawa Y, Tsujimura A, Nonomura N, Miyata H, Okabe M, Ikawa M, Kawakami Y, Goshima N, Wada M, Tanaka H.
    PLoS One. 2015 Apr 14;10(4):e0124293.

  50. A Simple and Robust Method for Establishing Homogeneous Mouse Epiblast Stem Cell Lines by Wnt Inhibition.
    Sugimoto M, Kondo M, Koga Y, Shiura H, Ikeda R, Hirose M, Ogura A, Murakami A, Yoshiki A, Chuva de Sousa Lopes SM, Abe K.
    Stem Cell Reports. 2015 Apr 14;4(4):744-57.

  51. Quantitative assessment of telomerase components in cancer cell lines.
    Akıncılar SC, Low KC, Liu CY, Yan TD, Oji A, Ikawa M, Li S, Tergaonkar V.
    FEBS Lett. 2015 Apr 13;589(9):974-84.

  52. One-step generation of multiple transgenic mouse lines using an improved Pronuclear Injection-based Targeted Transgenesis (i-PITT).
    Ohtsuka M, Miura H, Mochida K, Hirose M, Hasegawa A, Ogura A, Mizutani R, Kimura M, Isotani A, Ikawa M, Sato M, Gurumurthy CB.
    BMC Genomics. 2015 Apr 9;16:274.

  53. Forced Expression of Nanog or Esrrb Preserves the ESC Status in the Absence of Nucleostemin Expression.
    Katano M, Ema M, Nakachi Y, Mizuno Y, Hirasaki M, Suzuki A, Ueda A, Nishimoto M, Takahashi S, Okazaki Y, Okuda A.
    Stem Cells. 2015 Apr;33(4):1089-101.

  54. Identification of a novel E-box binding pyrrole-imidazole polyamide inhibiting MYC-driven cell proliferation.
    Mishra R, Watanabe T, Kimura MT, Koshikawa N, Ikeda M, Uekusa S, Kawashima H, Wang X, Igarashi J, Choudhury D, Grandori C, Kemp CJ, Ohira M, Verma NK, Kobayashi Y, Takeuchi J, Koshinaga T, Nemoto N, Fukuda N, Soma M, Kusafuka T, Fujiwara K, Nagase H.
    Cancer Sci. 2015 Apr;106(4):421-9.

  55. Induction of DNA methylation by artificial piRNA production in male germ cells.
    Itou D, Shiromoto Y, Shin-Ya Y, Ishii C, Nishimura T, Ogonuki N, Ogura A, Hasuwa H, Fujihara Y, Kuramochi-Miyagawa S, Nakano T.
    Curr Biol. 2015 Mar 30;25(7):901-6.

  56. TALEN-Mediated Gene Disruption on Y Chromosome Reveals Critical Role of EIF2S3Y in Mouse Spermatogenesis.
    Matsubara Y, Kato T, Kashimada K, Tanaka H, Zhi Z, Ichinose S, Mizutani S, Morio T, Chiba T, Ito Y, Saga Y, Takada S, Asahara H.
    Stem Cells Dev. 2015 May 15;24(10):1164-70.

  57. Functional Differences between GDNF-Dependent and FGF2-Dependent Mouse Spermatogonial Stem Cell Self-Renewal.
    Takashima S, Kanatsu-Shinohara M, Tanaka T, Morimoto H, Inoue K, Ogonuki N, Jijiwa M, Takahashi M, Ogura A, Shinohara T.
    Stem Cell Reports. 2015 Mar 10;4(3):489-502.

  58. Generation of cloned mice from adult neurons by direct nuclear transfer.
    Mizutani E, Oikawa M, Kassai H, Inoue K, Shiura H, Hirasawa R, Kamimura S, Matoba S, Ogonuki N, Nagatomo H, Abe K, Wakayama T, Aiba A, Ogura A.
    Biol Reprod. 2015 Mar;92(3):81.

  59. Genome-wide screening of aberrant DNA methylation which associated with gene expression in mouse skin cancers.
    Fujiwara K, Ghosh S, Liang P, Morien E, Soma M, Nagase H.
    Mol Carcinog. 2015 Mar;54(3):178-88.

  60. Functional compensation between Myc and PI3K signaling supports self-renewal of embryonic stem cells.
    Hishida T, Nakachi Y, Mizuno Y, Katano M, Okazaki Y, Ema M, Takahashi S, Hirasaki M, Suzuki A, Ueda A, Nishimoto M, Hishida-Nozaki Y, Vazquez-Ferrer E, Sancho-Martinez I, Izpisua Belmonte JC, Okuda A.
    Stem Cells. 2015 Mar;33(3):713-25.

  61. Gene regulation. Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells.
    Arner E, Daub CO, Vitting-Seerup K, Andersson R, Lilje B, Drabløs F, Lennartsson A, Rönnerblad M, Hrydziuszko O, Vitezic M, Freeman TC, Alhendi AM, Arner P, Axton R, Baillie JK, Beckhouse A, Bodega B, Briggs J, Brombacher F, Davis M, Detmar M, Ehrlund A, Endoh M, Eslami A, Fagiolini M, Fairbairn L, Faulkner GJ, Ferrai C, Fisher ME, Forrester L, Goldowitz D, Guler R, Ha T, Hara M, Herlyn M, Ikawa T, Kai C, Kawamoto H, Khachigian LM, Klinken SP, Kojima S, Koseki H, Klein S, Mejhert N, Miyaguchi K, Mizuno Y, Morimoto M, Morris KJ, Mummery C, Nakachi Y, Ogishima S, Okada-Hatakeyama M, Okazaki Y, Orlando V, Ovchinnikov D, Passier R, Patrikakis M, Pombo A, Qin XY, Roy S, Sato H, Savvi S, Saxena A, Schwegmann A, Sugiyama D, Swoboda R, Tanaka H, Tomoiu A, Winteringham LN, Wolvetang E, Yanagi-Mizuochi C, Yoneda M, Zabierowski S, Zhang P, Abugessaisa I, Bertin N, Diehl AD, Fukuda S, Furuno M, Harshbarger J, Hasegawa A, Hori F, Ishikawa-Kato S, Ishizu Y, Itoh M, Kawashima T, Kojima M, Kondo N, Lizio M, Meehan TF, Mungall CJ, Murata M, Nishiyori-Sueki H, Sahin S, Nagao-Sato S, Severin J, de Hoon MJ, Kawai J, Kasukawa T, Lassmann T, Suzuki H, Kawaji H, Summers KM, Wells C; FANTOM Consortium, Hume DA, Forrest AR, Sandelin A, Carninci P, Hayashizaki Y.
    Science. 2015 Feb 27;347(6225):1010-4.

  62. Naïve-like conversion enhances the difference in innate in vitro differentiation capacity between rabbit ES cells and iPS cells.
    Honsho K, Hirose M, Hatori M, Yasmin L, Izu H, Matoba S, Togayachi S, Miyoshi H, Sankai T, Ogura A, Honda A.
    J Reprod Dev. 2015 Feb 24;61(1):13-9.

  63. Involvement of histone H2B monoubiquitination in the regulation of mouse preimplantation development.
    Ooga M, Suzuki MG, Aoki F.
    J Reprod Dev. 2015;61(3):179-84.

  64. Single-step generation of rabbits carrying a targeted allele of the tyrosinase gene using CRISPR/Cas9.
    Honda A, Hirose M, Sankai T, Yasmin L, Yuzawa K, Honsho K, Izu H, Iguchi A, Ikawa M, Ogura A.
    Exp Anim. 2015 Feb 5;64(1):31-7.

  65. SMAD2 and p38 signaling pathways act in concert to determine XY primordial germ cell fate in mice.
    Wu Q, Fukuda K, Weinstein M, Graff JM, Saga Y.
    Development. 2015 Feb 1;142(3):575-86.

  66. Biotin-deficient diet induces chromosome misalignment and spindle defects in mouse oocytes.
    Tsuji A, Nakamura T, Shibata K.
    Biosci Biotechnol Biochem. 2015 Feb;79(2):292-9.

  67. Dppa3 expression is critical for generation of fully reprogrammed iPS cells and maintenance of Dlk1-Dio3 imprinting.
    Xu X, Smorag L, Nakamura T, Kimura T, Dressel R, Fitzner A, Tan X, Linke M, Zechner U, Engel W, Krishna Pantakani DV.
    Nat Commun. 2015 Jan 23;6:6008.

  68. Pluripotent stem cells derived from mouse primordial germ cells by small molecule compounds.
    Kimura T, Kaga Y, Sekita Y, Fujikawa K, Nakatani T, Odamoto M, Funaki S, Ikawa M, Abe K, Nakano T.
    Stem Cells. 2015 Jan;33(1):45-55.

  69. Runt-related transcription factor 2 attenuates the transcriptional activity as well as DNA damage-mediated induction of pro-apoptotic TAp73 to regulate chemosensitivity.
    Ozaki T, Sugimoto H, Nakamura M, Hiraoka K, Yoda H, Sang M, Fujiwara K, Nagase H.
    FEBS J. 2015 Jan;282(1):114-28.

  70. Identification of Frequent Differentially Methylated Region in Sporadic Bladder Cancers.
    Hasegawa R, Fujiwara K, Obinata D, Kawashima H, Shinojima Y, Igarashi J, Wang X, Ghosh S, Nagase H, Takahashi S.
    Urol Int. 2015;94(4):479-84.


2014

  1. Establishment of a novel model of chondrogenesis using murine embryonic stem cells carrying fibrodysplasia ossificans progressiva-associated mutant ALK2.
    Fujimoto M, Ohte S, Shin M, Yoneyama K, Osawa K, Miyamoto A, Tsukamoto S, Mizuta T, Kokabu S, Machiya A, Okuda A, Suda N, Katagiri T.
    Biochem Biophys Res Commun. 2014 Dec 12;455(3-4):347-52.

  2. Genome-wide analysis of DNA methylation dynamics during early human development.
    Okae H, Chiba H, Hiura H, Hamada H, Sato A, Utsunomiya T, Kikuchi H, Yoshida H, Tanaka A, Suyama M, Arima T.
    PLoS Genet. 2014 Dec 11;10(12):e1004868.

  3. Devising assisted reproductive technologies for wild-derived strains of mice: 37 strains from five subspecies of Mus musculus.
    Mochida K, Hasegawa A, Otaka N, Hama D, Furuya T, Yamaguchi Z, Ichikawa E, Ijuin M, Taguma K, Hashimoto M, Takashima R, Kadota M, Hiraiwa N, Mekada K, Yoshiki A, Ogura A.
    PLoS One. 2014 Dec 3;9(12):e114305.

  4. A novel Amh-Treck transgenic mouse line allows toxin-dependent loss of supporting cells in gonads.
    Shinomura M, Kishi K, Tomita A, Kawasumi M, Kanezashi H, Kuroda Y, Tsunekawa N, Ozawa A, Aiyama Y, Yoneda A, Suzuki H, Saito M, Picard JY, Kohno K, Kurohmaru M, Kanai-Azuma M, Kanai Y.
    Reproduction. 2014 Dec;148(6):H1-9.

  5. FGF8-FGFR1 signaling acts as a niche factor for maintaining undifferentiated spermatogonia in the mouse.
    Hasegawa K, Saga Y.
    Biol Reprod. 2014 Dec;91(6):145.

  6. Interaction of NANOS2 and NANOS3 with different components of the CNOT complex may contribute to the functional differences in mouse male germ cells.
    Suzuki A, Niimi Y, Saga Y.
    Biol Open. 2014 Nov 21;3(12):1207-16.

  7. Establishment of paternal genomic imprinting in mouse prospermatogonia analyzed by nuclear transfer.
    Kamimura S, Hatanaka Y, Hirasawa R, Matsumoto K, Oikawa M, Lee J, Matoba S, Mizutani E, Ogonuki N, Inoue K, Kohda T, Ishino F, Ogura A.
    Biol Reprod. 2014 Nov;91(5):120.

  8. HSP90α plays an important role in piRNA biogenesis and retrotransposon repression in mouse.
    Ichiyanagi T, Ichiyanagi K, Ogawa A, Kuramochi-Miyagawa S, Nakano T, Chuma S, Sasaki H, Udono H.
    Nucleic Acids Res. 2014 Oct 29;42(19):11903-11.

  9. Inhibition of maintenance DNA methylation by Stella.
    Funaki S, Nakamura T, Nakatani T, Umehara H, Nakashima H, Nakano T.
    Biochem Biophys Res Commun. 2014 Oct 24;453(3):455-60.

  10. The Trp53-Trp53inp1-Tnfrsf10b Pathway Regulates the Radiation Response of Mouse Spermatogonial Stem Cells.
    Ishii K, Ishiai M, Morimoto H, Kanatsu-Shinohara M, Niwa O, Takata M, Shinohara T.
    Stem Cell Reports. 2014 Oct 14;3(4):676-89.

  11. Intracellular fragment of NLRR3 (NLRR3-ICD) stimulates ATRA-dependent neuroblastoma differentiation.
    Akter J, Takatori A, Islam MS, Nakazawa A, Ozaki T, Nagase H, Nakagawara A.
    Biochem Biophys Res Commun. 2014 Oct 10;453(1):86-93.

  12. The hypoxia-inducible epigenetic regulators Jmjd1a and G9a provide a mechanistic link between angiogenesis and tumor growth.
    Ueda J, Ho JC, Lee KL, Kitajima S, Yang H, Sun W, Fukuhara N, Zaiden N, Chan SL, Tachibana M, Shinkai Y, Kato H, Poellinger L.
    Mol Cell Biol. 2014 Oct 1;34(19):3702-20.

  13. Induction of the G2/M transition stabilizes haploid embryonic stem cells.
    Takahashi S, Lee J, Kohda T, Matsuzawa A, Kawasumi M, Kanai-Azuma M, Kaneko-Ishino T, Ishino F.
    Development. 2014 Oct;141(20):3842-7.

  14. Improved serum- and feeder-free culture of mouse germline stem cells.
    Kanatsu-Shinohara M, Ogonuki N, Matoba S, Morimoto H, Ogura A, Shinohara T.
    Biol Reprod. 2014 Oct;91(4):88.

  15. Pyrrole-imidazole polyamide targeted to break fusion sites in TMPRSS2 and ERG gene fusion represses prostate tumor growth.
    Obinata D, Ito A, Fujiwara K, Takayama K, Ashikari D, Murata Y, Yamaguchi K, Urano T, Fujimura T, Fukuda N, Soma M, Watanabe T, Nagase H, Inoue S, Takahashi S.
    Cancer Sci. 2014 Oct;105(10):1272-8.

  16. Induction of primordial germ cell-like cells from mouse embryonic stem cells by ERK signal inhibition.
    Kimura T, Kaga Y, Ohta H, Odamoto M, Sekita Y, Li K, Yamano N, Fujikawa K, Isotani A, Sasaki N, Toyoda M, Hayashi K, Okabe M, Shinohara T, Saitou M, Nakano T.
    Stem Cells. 2014 Oct;32(10):2668-78.

  17. Genomic aspects of common diseases.
    Muramatsu M, Okuda A, Okazaki Y.
    Biochem Biophys Res Commun. 2014 Sep 19;452(2):211-2.

  18. Setdb1 is required for germline development and silencing of H3K9me3-marked endogenous retroviruses in primordial germ cells.
    Liu S, Brind'Amour J, Karimi MM, Shirane K, Bogutz A, Lefebvre L, Sasaki H, Shinkai Y, Lorincz MC.
    Genes Dev. 2014 Sep 15;28(18):2041-55.

  19. Identification of Ccr4-not complex components as regulators of transition from partial to genuine induced pluripotent stem cells.
    Kamon M, Katano M, Hiraki-Kamon K, Hishida T, Nakachi Y, Mizuno Y, Okazaki Y, Suzuki A, Hirasaki M, Ueda A, Nishimoto M, Kato H, Okuda A.
    Stem Cells Dev. 2014 Sep 15;23(18):2170-9.

  20. Simple generation of albino C57BL/6J mice with G291T mutation in the tyrosinase gene by the CRISPR/Cas9 system.
    Mizuno S, Dinh TT, Kato K, Mizuno-Iijima S, Tanimoto Y, Daitoku Y, Hoshino Y, Ikawa M, Takahashi S, Sugiyama F, Yagami K.
    Mamm Genome. 2014 Aug;25(7-8):327-34.

  21. Deletion of N-myc downstream-regulated gene 2 attenuates reactive astrogliosis and inflammatory response in a mouse model of cortical stab injury.
    Takarada-Iemata M, Kezuka D, Takeichi T, Ikawa M, Hattori T, Kitao Y, Hori O.
    J Neurochem. 2014 Aug;130(3):374-87.

  22. Small RNA profiling and characterization of piRNA clusters in the adult testes of the common marmoset, a model primate.
    Hirano T, Iwasaki YW, Lin ZY, Imamura M, Seki NM, Sasaki E, Saito K, Okano H, Siomi MC, Siomi H.
    RNA. 2014 Aug;20(8):1223-37.

  23. Application of detergents or high hydrostatic pressure as decellularization processes in uterine tissues and their subsequent effects on in vivo uterine regeneration in murine models.
    Santoso EG, Yoshida K, Hirota Y, Aizawa M, Yoshino O, Kishida A, Osuga Y, Saito S, Ushida T, Furukawa KS.
    PLoS One. 2014 Jul 24;9(7):e103201.

  24. Yb integrates piRNA intermediates and processing factors into perinuclear bodies to enhance piRISC assembly.
    Murota Y, Ishizu H, Nakagawa S, Iwasaki YW, Shibata S, Kamatani MK, Saito K, Okano H, Siomi H, Siomi MC.
    Cell Rep. 2014 Jul 10;8(1):103-13.

  25. Offspring production with sperm grown in vitro from cryopreserved testis tissues.
    Yokonishi T, Sato T, Komeya M, Katagiri K, Kubota Y, Nakabayashi K, Hata K, Inoue K, Ogonuki N, Ogura A, Ogawa T.
    Nat Commun. 2014 Jul 1;5:4320.

  26. MicroRNA-200a locally attenuates progesterone signaling in the cervix, preventing embryo implantation.
    Haraguchi H, Saito-Fujita T, Hirota Y, Egashira M, Matsumoto L, Matsuo M, Hiraoka T, Koga K, Yamauchi N, Fukayama M, Bartos A, Cha J, Dey SK, Fujii T, Osuga Y.
    Mol Endocrinol. 2014 Jul;28(7):1108-17.

  27. Inhibition of human osteosarcoma cell migration and invasion by a gene silencer, pyrrole-imidazole polyamide, targeted at the human MMP9 NF-κB binding site.
    Kojima T, Wang X, Fujiwara K, Osaka S, Yoshida Y, Osaka E, Taniguchi M, Ueno T, Fukuda N, Soma M, Tokuhashi Y, Nagase H.
    Biol Pharm Bull. 2014;37(9):1460-5.

  28. NUCKS is a positive transcriptional regulator of insulin signaling.
    Qiu B, Shi X, Wong ET, Lim J, Bezzi M, Low D, Zhou Q, Akıncılar SC, Lakshmanan M, Swa HL, Tham JM, Gunaratne J, Cheng KK, Hong W, Lam KS, Ikawa M, Guccione E, Xu A, Han W, Tergaonkar V.
    Cell Rep. 2014 Jun 26;7(6):1876-86.

  29. Skp1-Cullin-F-box (SCF)-type ubiquitin ligase FBXW7 negatively regulates spermatogonial stem cell self-renewal.
    Kanatsu-Shinohara M, Onoyama I, Nakayama KI, Shinohara T.
    Proc Natl Acad Sci U S A. 2014 Jun 17;111(24):8826-31.

  30. LINE-1 of evidence for fetal oocyte attrition by retrotransposon.
    Chuma S
    Dev Cell. 2014 Jun 9;29(5):501-2.

  31. Transgenic expression of Map3k4 rescues T-associated sex reversal (Tas) in mice.
    Warr N, Siggers P, Carré GA, Bogani D, Brixey R, Akiyoshi M, Tachibana M, Teboul L, Wells S, Sanderson J, Greenfield A.
    Hum Mol Genet. 2014 Jun 1;23(11):3035-44.

  32. DNMT3L promotes quiescence in postnatal spermatogonial progenitor cells.
    Liao HF, Chen WS, Chen YH, Kao TH, Tseng YT, Lee CY, Chiu YC, Lee PL, Lin QJ, Ching YH, Hata K, Cheng WT, Tsai MH, Sasaki H, Ho HN, Wu SC, Huang YH, Yen P, Lin SP.
    Development. 2014 Jun;141(12):2402-13.

  33. CYP26B1 promotes male germ cell differentiation by suppressing STRA8-dependent meiotic and STRA8-independent mitotic pathways.
    Saba R, Wu Q, Saga Y.
    Dev Biol. 2014 May 15;389(2):173-81.

  34. Nr4a3, a possibile oncogenic factor for neuroblastoma associated with CpGi methylation within the third exon.
    Uekusa S, Kawashima H, Sugito K, Yoshizawa S, Shinojima Y, Igarashi J, Ghosh S, Wang X, Fujiwara K, Ikeda T, Koshinaga T, Soma M, Nagase H.
    Int J Oncol. 2014 May;44(5):1669-77.

  35. A novel gene regulator, pyrrole-imidazole polyamide targeting ABCA1 gene increases cholesterol efflux from macrophages and plasma HDL concentration.
    Tsunemi A1, Ueno T, Fukuda N, Watanabe T, Tahira K, Haketa A, Hatanaka Y, Tanaka S, Matsumoto T, Matsumoto Y, Nagase H, Soma M.
    J Mol Med (Berl). 2014 May;92(5):509-21.

  36. Whole-mount MeFISH: a novel technique for simultaneous visualization of specific DNA methylation and protein/RNA expression.
    Shiura H, Okamoto A, Sasaki H, Abe K.
    PLoS One. 2014 Apr 22;9(4):e95750.

  37. Role of Retinoic Acid and Fibroblast Growth Factor 2 in Neural Differentiation from Cynomolgus Monkey (Macaca fascicularis) Embryonic Stem Cells.
    Hatori M, Shimozawa N, Yasmin L, Suemori H, Nakatsuji N, Ogura A, Yagami K, Sankai T.
    Comp Med. 2014 Apr;64(2):140-7.

  38. A novel mutation in the thyroglobulin gene that causes goiter and dwarfism in Wistar Hannover GALAS rats.
    Sato A, Abe K, Yuzuriha M, Fujii S, Takahashi N, Hojo H, Teramoto S, Aoyama H.
    Mutat Res. 2014 Apr;762:17-23.

  39. GPI-Anchored Protein Complex, LY6K/TEX101, Is Required for Sperm Migration into the Oviduct and Male Fertility in Mice.
    Fujihara Y, Okabe M, Ikawa M.
    Biol Reprod. 2014 Mar 20;90(3):60.

  40. Cell-cycle-dependent colonization of mouse spermatogonial stem cells after transplantation into seminiferous tubules.
    Ishii K, Kanatsu-Shinohara M, Shinohara T.
    J Reprod Dev. 2014 Mar 7;60(1):37-46.

  41. Microdroplet In Vitro Fertilization Can Reduce the Number of Spermatozoa Necessary for Fertilizing Oocytes.
    Hasegawa A, Mochida K, Tomishima T, Inoue K, Ogura A.
    J Reprod Dev. 2014;60(3):187-93.

  42. RNA sequencing-based identification of aberrant imprinting in cloned mice.
    Okae H, Matoba S, Nagashima T, Mizutani E, Inoue K, Ogonuki N, Chiba H, Funayama R, Tanaka S, Yaegashi N, Nakayama K, Sasaki H, Ogura A, Arima T.
    Hum Mol Genet. 2014 Feb 15;23(4):992-1001.

  43. Liver-Specific γ-Glutamyl Carboxylase-Deficient Mice Display Bleeding Diathesis and Short Life Span.
    Azuma K, Tsukui T, Ikeda K, Shiba S, Nakagawa K, Okano T, Urano T, Horie-Inoue K, Ouchi Y, Ikawa M, Inoue S.
    PLoS One. 2014 Feb 10;9(2):e88643.

  44. Histone variants enriched in oocytes enhance reprogramming to induced pluripotent stem cells.
    Shinagawa T, Takagi T, Tsukamoto D, Tomaru C, Huynh LM, Sivaraman P, Kumarevel T, Inoue K, Nakato R, Katou Y, Sado T, Takahashi S, Ogura A, Shirahige K, Ishii S.
    Cell Stem Cell. 2014 Feb 6;14(2):217-27.

  45. Understanding the X chromosome inactivation cycle in mice: a comprehensive view provided by nuclear transfer.
    Oikawa M, Inoue K, Shiura H, Matoba S, Kamimura S, Hirose M, Mekada K, Yoshiki A, Tanaka S, Abe K, Ishino F, Ogura A.
    Epigenetics. 2014 Feb 1;9(2):204-11.

  46. A heterozygous mutation of GALNTL5 affects male infertility with impairment of sperm motility.
    Takasaki N, Tachibana K, Ogasawara S, Matsuzaki H, Hagiuda J, Ishikawa H, Mochida K, Inoue K, Ogonuki N, Ogura A, Noce T, Ito C, Toshimori K, Narimatsu H.
    Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):1120-5.

  47. Active DNA demethylation is required for complete imprint erasure in primordial germ cells.
    Kawasaki Y, Lee J, Matsuzawa A, Kohda T, Kaneko-Ishino T, Ishino F.
    Sci Rep. 2014 Jan 13;4:3658.

  48. Feasibility for a large scale mouse mutagenesis by injecting CRISPR/Cas plasmid into zygotes.
    Mashiko D, Young SA, Muto M, Kato H, Nozawa K, Ogawa M, Noda T, Kim YJ, Satouh Y, Fujihara Y, Ikawa M.
    Dev Growth Differ. 2014 Jan;56(1):122-9.

  49. NANOS2 promotes male germ cell development independent of meiosis suppression.
    Saba R, Kato Y, Saga Y.
    Dev Biol. 2014 Jan 1;385(1):32-40.
  50. Effect of isolated AMP deaminase deficiency on skeletal muscle function.
    Chenga j, Morisaki H, Sugimoto N, Dohi A, Shintani T, Kimura E, Toyama K, Ikawa M, Okabe M, Higuchi I, Matsuo S, Kawai Y, Hisatome I, Sugama T, Holmes E. W. , Morisaki T.
    Molecular Genetics and Metabolism Reports 2014;1:51-9

2013

  1. Enrichment of mouse spermatogonial stem cells based on aldehyde dehydrogenase activity.
    Kanatsu-Shinohara M, Mori Y, Shinohara T.
    Biol Reprod 2013 Dec;89(6):140.

  2. Generation of mutant mice by pronuclear injection of circular plasmid expressing Cas9 and single guided RNA.
    Mashiko D, Fujihara Y, Satouh Y, Miyata H, Isotani A, Ikawa M.
    Sci Rep. 2013 Nov 27;3:3355.

  3. MEK/ERK signaling directly and indirectly contributes to the cyclical self-renewal of spermatogonial stem cells.
    Hasegawa K, Namekawa SH, Saga Y.
    Stem Cells. 2013 Nov;31(11):2517-27.

  4. Somatic donor cell type correlates with embryonic, but not extra-embryonic, gene expression in postimplantation cloned embryos.
    Hirasawa R, Matoba S, Inoue K, Ogura A.
    PLoS One. 2013 Oct 16;8(10):e76422.

  5. Tudor domain containing 12 (TDRD12) is essential for secondary PIWI interacting RNA biogenesis in mice.
    Pandey RR, Tokuzawa Y, Yang Z, Hayashi E, Ichisaka T, Kajita S, Asano Y, Kunieda T, Sachidanandam R, Chuma S, Yamanaka S, Pillai RS.
    Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16492-7

  6. Identification of the KDM2/7 Histone Lysine Demethylase Subfamily Inhibitor and its Antiproliferative Activity.
    Suzuki, T., Ozasa, H., Itoh, Y., Zhan, P., Sawada, H., Mino, K., Walport, L., Ohkubo, R., Kawamura, A., Yonezawa, M., Tsukada, Y., Tumber, A., Nakagawa, H., Hasegawa, M., Sasaki, R., Mizukami, T., Schofield, C., Miyata, N.
    J. Med. Chem., 2013 Sep 26;56(18):7222-31.

  7. Regulation of pluripotency in male germline stem cells by Dmrt1.
    Takashima S, Hirose M, Ogonuki N, Ebisuya M, Inoue K, Kanatsu-Shinohara M, Tanaka T, Nishida E, Ogura A, Shinohara T.
    Genes Dev. 2013 Sep 15;27(18):1949-58.

  8. Epigenetic regulation of mouse sex determination by the histone demethylase Jmjd1a.
    Kuroki S, Matoba S, Akiyoshi M, Matsumura Y, Miyachi H, Mise N, Abe K, Ogura A, Wilhelm D, Koopman P, Nozaki M, Kanai Y, Shinkai Y, Tachibana M.
    Science. 2013 Sep 6;341(6150):1106-9.

  9. Naive-like conversion overcomes the limited differentiation capacity of induced pluripotent stem cells.
    Honda A, Hatori M, Hirose M, Honda C, Izu H, Inoue K, Hirasawa R, Matoba S, Togayachi S, Miyoshi H, Ogura A.
    J Biol Chem. 2013 Sep 6;288(36):26157-66.

  10. The nuage mediates retrotransposon silencing in mouse primordial ovarian follicles.
    Lim AK, Lorthongpanich C, Chew TG, Tan CW, Shue YT, Balu S, Gounko N, Kuramochi-Miyagawa S, Matzuk MM, Chuma S, Messerschmidt DM, Solter D, Knowles BB.
    Development. 2013 Sep;140(18):3819-25

  11. The Arf GAP SMAP2 is necessary for organized vesicle budding from the trans-Golgi network and subsequent acrosome formation in spermiogenesis.
    Funaki T, Kon S, Tanabe K, Natsume W, Sato S, Shimizu T, Yoshida N, Wong WF, Ogura A, Ogawa T, Inoue K, Ogonuki N, Miki H, Mochida K, Endoh K, Yomogida K, Fukumoto M, Horai R, Iwakura Y, Ito C, Toshimori K, Watanabe T, Satake M.
    Mol Biol Cell. 2013 Sep;24(17):2633-44.

  12. Targeted disruption of fad24, a regulator of adipogenesis, causes pre-implantation embryonic lethality due to the growth defect at the blastocyst stage.
    Ochiai N, Nishizuka M, Miyamoto T, Miyoshi I, Ikawa M, Osada S, Imagawa M.
    Biochem Biophys Res Commun. 2013 Aug 23;438(2):301-5.

  13. Establishment of mouse model of MYH9 disorders: heterozygous R702C mutation provokes macrothrombocytopenia with leukocyte inclusion bodies, renal glomerulosclerosis and hearing disability.
    Suzuki N, Kunishima S, Ikejiri M, Maruyama S, Sone M, Takagi A, Ikawa M, Okabe M, Kojima T, Saito H, Naoe T, Matsushita T.
    PLoS One. 2013 Aug 20;8(8):e71187.

  14. Macrophage MHC and T-cell receptors essential for rejection of allografted skin and lymphoma.
    Tashiro-Yamaji J, Maeda S, Ikawa M, Okabe M, Kubota T, Yoshida R.
    Transplantation. 2013 Aug 15;96(3):251-7.

  15. DmGTSF1 is necessary for Piwi-piRISC-mediated transcriptional transposon silencing in the Drosophila ovary.
    Ohtani H, Iwasaki YW, Shibuya A, Siomi H, Siomi MC, Saito K.
    Genes Dev. 2013 Aug 1;27(15):1656-61.

  16. Mouse cloning using a drop of peripheral blood.
    Kamimura S, Inoue K, Ogonuki N, Hirose M, Oikawa M, Yo M, Ohara O, Miyoshi H, Ogura A.
    Biol Reprod. 2013 Aug 1;89(2):24.

  17. Molecular dissection of IZUMO1, a sperm protein essential for sperm-egg fusion.
    Inoue N, Hamada D, Kamikubo H, Hirata K, Kataoka M, Yamamoto M, Ikawa M, Okabe M and Hagihara Y.
    Development.2013 Aug;140(15):3221-9.

  18. Mice stage-specific claudin 3 expression regulates progression of meiosis in early stage spermatocytes.
    Chihara M, Ikebuchi R, Otsuka S, Ichii O, Hashimoto Y, Suzuki A, Saga Y, Kon Y.
    Biol Reprod. 2013 Jul 5;89(1):3.

  19. MiR-200b and miR-429 Function in Mouse Ovulation and Are Essential for Female Fertility.
    Hasuwa H, Ueda J, Ikawa M, Okabe M.
    Science. 2013 Jul 5;341(6141):71-3.

  20. Generation of a novel germline stem cell line expressing a germline-specific reporter in the mouse.
    Shiura H, Ikeda R, Lee J, Sato T, Ogonuki N, Hirose M, Ogura A, Ogawa T, Abe K.
    Genesis. 2013 Jul;51(7):498-505.

  21. t-SNARE Syntaxin2 (STX2) is implicated in intracellular transport of sulfoglycolipids during meiotic prophase in mouse spermatogenesis.
    Fujiwara Y, Ogonuki N, Inoue K, Ogura A, Handel MA, Noguchi J, Kunieda T.
    Biol Reprod. 2013 Jun 6;88(6):141.

  22. ROS are required for mouse spermatogonial stem cell self-renewal.
    Morimoto H, Iwata K, Ogonuki N, Inoue K, Atsuo O, Kanatsu-Shinohara M, Morimoto T, Yabe-Nishimura C, Shinohara T.
    Cell Stem Cell. 2013 Jun 6;12(6):774-86.

  23. Recruitment of cyclin G2 to promyelocytic leukemia nuclear bodies promotes dephosphorylation of γH2AX following treatment with ionizing radiation.
    Naito Y, Yabuta N, Sato J, Ohno S, Sakata M, Kasama T, Ikawa M, Nojima H.
    Cell Cycle. 2013 Jun 1;12(11):1773-84.

  24. GPAT2, a mitochondrial outer membrane protein, in piRNA biogenesis in germline stem cells.
    Shiromoto Y, Kuramochi-Miyagawa S, Daiba A, Chuma S, Katanaya A, Katsumata A, Nishimura K, Ohtaka M, Nakanishi M, Nakamura T, Yoshinaga K, Asada N, Nakamura S, Yasunaga T, Kojima-Kita K, Itou D, Kimura T, Nakano T.
    RNA. 2013 Jun;19(6):803-10

  25. Expression of TEX101, regulated by ACE, is essential for the production of fertile mouse spermatozoa.
    Fujihara Y, Tokuhiro K, Muro Y, Kondoh G, Araki Y, Ikawa M, Okabe M.
    Proc Natl Acad Sci U S A. 2013 May 14;110(20):8111-6.

  26. Effects of dppa3 on DNA methylation dynamics during primordial germ cell development in mice.
    Nakashima H, Kimura T, Kaga Y, Nakatani T, Seki Y, Nakamura T, Nakano T.
    Biol Reprod. 2013 May 23;88(5):125

  27. RNAi-mediated knockdown of Xist does not rescue the impaired development of female cloned mouse embryos.
    Oikawa M, Matoba S, Inoue K, Kamimura S, Hirose M, Ogonuki N, Shiura H, Sugimoto M, Abe K, Ishino F, Ogura A.
    J Reprod Dev. 2013;59(3):231-7.


 Review/Book  2016  2015 2014 2013

For Original Articles, please click


2016

  1. Nucleolus Precursor Bodies and Ribosome Biogenesis in Early Mammalian Embryos: Old Theories and New Discoveries.
    Fulka H, Aoki F.
    Biol Reprod. 2016 Jun;94(6):143.

  2. A New, Dynamic Era for Somatic Cell Nuclear Transfer?
    Loi P, Iuso D, Czernik M, Ogura A.
    Trends Biotechnol. 2016 Apr 22.[Epub ahead of print]

  3. GPI-AP release in cellular, developmental, and reproductive biology.
    Fujihara Y, Ikawa M.
    Lipid Res. 2016 Apr;57(4):538-45.

  4. Epigenetics of sex determination in mammals
    Tachibana M.
    Reproductive Medicine and Biology 2016 Apr;15:59-67

2015

  1. Stella and Zygotic Reprogramming
    Nakamura T, Nakano T.
    In "Epigenetic Mechanisms in Cellular Reprogramming", Epigenetics and Human Health series, Springer 2015;31-42

  2. How does Progesterone Support Embryo Implantation?
    Hiraoka T, Saito-Fujita T, Hirota Y.
    J Mamm Ova Res 2015 Oct;32: 87-94

  3. From Sex Determination to Initial Folliculogenesis in Mammalian Ovaries: Morphogenetic Waves along the Anteroposterior and Dorsoventral Axes.
    Suzuki H, Kanai-Azuma M, Kanai Y.
    Sex Dev. 2015;9(4);190-204.

  4. Epigenetic alterations in sperm associated with male infertility.
    Kitamura A, Miyauchi N, Hamada H, Hiura H, Chiba H, Okae H, Sato A, John RM, Arima T.
    Congenit Anom. 2015 Aug;55(3):133-44.

  5. Advantages of using the CRISPR/Cas9 system of genome editing to investigate male reproductive mechanisms using mouse models.
    Young SA, Aitken RJ, Ikawa M.
    Asian J Androl. 2015 Jul-Aug;17(4):623-7.

  6. Epigenetic regulation of mammalian sex determination.
    Tachibana M.
    J Med Invest. 2015;62(1-2):19-23.

2014

  1. Imprinting methylation errors in ART
    Hiura H, Okae H, Chiba H, Miyauchi N, Sato F, Sato A, Arima T.
    Reprod Med Biol. 2014;13(4):193-202

  2. piRNA clusters and open chromatin structure.
    Yamanaka S, Siomi MC, Siomi H.
    Mob DNA. 2014;5:22

  3. RNAi and overexpression of genes in ovarian somatic cells.
    Saito K.
    Methods Mol Biol. 2014;1093:25-33

  4. Genome Editing in Mice Using CRISPR/Cas. Targeted Genome Editing Using Site-Specific Nucleases
    Young S, Baker M, Ikawa M.
    Springer Japan 2014;151-166

  5. CRISPR/Cas9-based genome editing in mice by single plasmid injection.
    Fujihara Y, Ikawa M.
    Methods Enzymol. 2014;546:319-36

  6. RNAi and overexpression of genes in ovarian somatic cells.
    Saito K.
    Methods Mol Biol. 2014;1093:25-33.

2013

  1. Embryo manipulation via assisted reproductive technology and epigenetic asymmetry in mammalian early development.
    Kohda T, Ishino F.
    Philos Trans R Soc Lond B Biol Sci. 2013;368(1609):20120353

  2. Symposium in honor of Ralph L. Brinster celebrating 50 years of scientific breakthroughs.
    Behringer RR, Shinohara T.
    Int J Dev Biol. 2013;57(5):333-9

  3. Spermatogonial Stem Cell Self-Renewal and Development.
    Kanatsu-Shinohara M, Shinohara T.
    Annu Rev Cell Dev Biol. 2013 Oct 6;29:163-187.

  4. The discovery of histone demethylases.
    Shi, Y., Tsukada, Y.
    Cold Spring Harb. Perspect. Biol. 2013 Sep 1;5(9). pii: a017947.

  5. Effects of embryonic manipulation and epigenetics.
    Kohda T.
    J Hum Genet. 2013 Jul;58(7):416-20.

  6. The epigenetic regulation of transposable elements by PIWI-interacting RNAs in Drosophila.
    Saito K.
    Genes Genet Syst. 2013;88(1):9-17.

  7. Clone-specific X-linked gene repression caused by ectopic Xist transcripts from the active X chromosome.
    Ogura A, Inoue K.
    Principles of Cloning, 2nd Edition, 2013: 161-172, Jose Cibelli et al., ed., Elsevier

Contact

Head investigator:
Prof. Takashi Shinohara

Department of Molecular Genetics, Graduate School of Medicine, Kyoto University.

Yoshida-Konoe-cho,Sakyo-ku, Kyoto 606-8501, Japan

Secretariat:
Prof. Masahito Ikawa

Animal Resource Center for Infectious Diseases, Research Institute for Microbial Diseases, Osaka University.

Yamadaoka 3-1, Suita, Osaka 565-0871, Japan

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