International Activity Support

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International Cooperative Research(started in 2015)


updated on 2017.08.23

Takashi Shinohara group

  1. John McCarrey(The University of Texas at San Antonio, USA)
  2. Makoto Nagano(McGill University, Canada)

Atsuo Ogura group

  1. Pasqualino Loi(University of Teramo, Italy)
  2. Helena Fulka(Institute of Molecular Genetics, Czechoslovakia)
  3. Jeremy Swann (Max Planck Institute of Immunobiology and Epigentics, Germany)

Masahito Ikawa group

  1. Martin Matzuk(Baylor College of Medicine, USA)
  2. SungHee Baek(Seoul National University, Korea)

Hitomi Suzuki group

  1. Aleksandar Rajkovic(University of Pittsburgh, USA)

Soiichiro Yamanaka group

  1. Active Motif company(USA)

Fugaku Aoki group

  1. Heng-Yu Fan (Life Sciences Institute, Zhejiang University, China)

Kei Miyamoto group

  1. Robert Grosse (Philipps-Universität Marburg, Germany)
  2. Piergiorgio Percipalle (New York University Abu Dhabi, UAE)
  3. Antonio Adamo (King Abdulaziz University (KAUST) , Saudi Arabia)

Akihiko Okuda group

  1. Robert Eisenman (Fred Huchinson Cancer Research Institute, USA)

Yoshiyuki Seki group

  1. Andrew Johnson (The University of Nottingham, USA)

Overseas Presentations by Young Researchers


  1. Kenichiro Abe(Aoki group)- Currently in Helmholtz Zentrum München(Germany), and visited Aoki lab
    Date: May, 2017
    Report (In Japanese)

  2. Akane Masuko(Saito group)- Attended the Keystone Symposium at Canada
    Date: February 5-7, 2017
    Conference: Keystone Symposium @ Fairmont Banff Springs, Alberta, Canada  
    Report (In Japanese)

  3. Kota Inoue(Sasaki group)- Poster presentation
    Date: January 26-27, 2017
    Conference: 11th International Symposium of The Institute Network, "Frontiers in Biomedical Sciences" @ Tokushima  


  1. Asuka Furuta(Nakamura group)- Presented at CSH meeting Germ Cells
    Date: October 4-8, 2016
    Conference: CSH meeting Germ Cells @ Cold Spring Harbor Laboratory
    Title: Induction of totipotent fraction in ES cell culture

  2. Yuki Hamada(Okae group)- Presented (poster) at IFPA 2016
    Date: September 12-18, 2016
    Conference: IFPA 2016 Placenta: Back to the Basics @ Portland, Oregon
    Title: Incomplete programming of germline DNA methylation in the human placenta

  3. Yuki Hatanaka(Ogura group)- Presented at Mouse Genetics 2016
    Date: July 13-17, 2016
    Conference: Mouse Genetics 2016 @ Orlando World Center Marriot
    Title: Histone H3R17me2a Mark Recruits Tet3 to Initiate Active DNA Demethylation in mouse Zygotes Report (In Japanese)

  4. Kurumi Fukuda(Saga group)- Presented at The Allied Genetics Conference(TAGC)
    Date: July 13-17, 2016
    Conference: The Allied Genetics Conference @ Orlando, Florida
    Report (In Japanese)

  5. Hitomi Matsuzaki(Tanimoto group)- Presented at Mouse Genetics 2016
    Date: July 13-17, 2016
    Conference: Mouse Genetics 2016 @ Orlando World Center Marriot
    Title: Imprinted DNA methylation status can be reconstituted by combining activity of distinct H19 ICR elements in mice

  6. Shoji Maenohara(Sasaki group)- Received Best Poster Award
    Date: May 9-13, 2016
    Conference: The 4th Cold Spring Harbor Asia conference on Chromatin, Epigenetics and Transcription @ Suzhou, China

  7. Kenjiro Shirane(Sasaki group)- Chosen to speak at the short talk session
    Date: May 9-13, 2016
    Conference: The 4th Cold Spring Harbor Asia conference on Chromatin, Epigenetics and Transcription @ Suzhou, China

  8. Yuka Kabayama(Sasaki group)- Poster presentaion
    Date: May 9-13, 2016
    Conference: The 4th Cold Spring Harbor Asia conference on Chromatin, Epigenetics and Transcription @ Suzhou, China

  9. Domenico Iuso(Ogura group)- Excellence Award
    Date: March 10, 2016
    Conference: International Symposium on the Future of Nuclear Transfer and Nuclear Reprogramming @ Yamanashi University 

  10. Haruhiko Miyata(Ikawa group)- Selected for presentation at the conference abroad for its excellence
    Date: February 27-March 2, 2016
    Conference: Biophysical Society 60th Annual Meeting @ Los Angeles Convention Center  
    Title: Sperm Calcineurin is Necessary for Midpiece Flexibility and Male Fertility

Achievements through International Cooperative Research


  1. Shinohara, Eisenman, Trumpp et al - Publication in Genes & development
    Myc/Mycn-mediated glycolysis enhances mouse spermatogonial stem cell self-renewal.
    Genes Dev. 2016 Dec 1;30(23):2637-2648. doi: 10.1101/gad.287045.116.
    PICK-UP Topics(Japanese)

  2. Tachibana, Soares et al - Publication in Proc Natl Acad Sci USA
    niA HIF-KDM3A-MMP12 regulatory circuit ensures trophoblast plasticity and placental adaptations to hypoxia.
    Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):E7212-E7221. Epub 2016 Nov 2

  3. Ishizu, Andrenacci, et al - Publication in Genetics
    Production of Small Noncoding RNAs from the flamenco Locus Is Regulated by the gypsy Retrotransposon of Drosophila melanogaster.
    Genetics. 2016 Oct;204(2):631-644. Epub 2016 Aug 24.

  4. Ogura, Iuso et al - Publication in Trends in Biotechnology
    A New, Dynamic Era for Somatic Cell Nuclear Transfer?
    Trends Biotechnol. 2016 Oct;34(10):791-7. doi: 10.1016/j.tibtech.2016.03.008. Epub 2016 Apr 22.

  5. Miyamoto, Gurdon, Jullien et al - Publication in Genome Res
    Sperm is epigenetically programmed to regulate gene transcription in embryos.
    Genome Res. 2016 Aug;26(8):1034-46. doi: 10.1101/gr.201541.115.

  6. Shinohara, Lei, Rao et al - Publication in Stem Cell Reports
    The Luteinizing Hormone-Testosterone Pathway Regulates Mouse Spermatogonial Stem Cell Self-Renewal by Suppressing WNT5A Expression in Sertoli Cells.
    Stem Cell Reports. 2016 Aug 9;7(2):279-91. doi: 10.1016/j.stemcr.2016.07.005.
    PICK-UP Topics(Japanese)

  7. Ikawa, Matzuk et al - Publication in Proc Natl Acad Sci USA
    Genome engineering uncovers 54 evolutionarily conserved and testis-enriched genes that are not required for male fertility in mice.
    Proc Natl Acad Sci USA. 2016 Jul 12;113(28):7704-10. doi: 10.1073/pnas.1608458113. Epub 2016 Jun 29.
    PICK-UP Topics(Japanese)

  8. Aoki, Fulka et al - Publication in Biol Reprod
    Nucleolus Precursor Bodies and Ribosome Biogenesis in Early Mammalian Embryos: Old Theories and New Discoveries.
    Biol Reprod. 2016 Jun;94(6):143. doi: 10.1095/biolreprod.115.136093. Epub 2016 Mar 2.

Upcoming International Cooperative Research Plans

  1. Prof. de Rooij from the Laboratory for Reproductive Biology, Center for Reproductive Medicine Women's and Children's Hospital(The Netherlands) will coming to Japan.
    Please contact us for more details.

  2. Prof. Yanagimachi from the Institute for Biogenesis Research (University of Hawaii) will be planning to present at the 5th International Symposium in November.
    Please contact us for any inquiries.

  3. WCRB2017(9.27-9.29) will be held in Okinawa. Many reproductive biologists including Prof. Helena and Prof. Matzuk are planning to attend.
    For discussion requests, please email us.

  4. Prof. Allan Balmain is planning to attend The 76th Annual Meeting of the Japanese Cancer Association(2017.09.28-30).
    Please contact us for more details.

  5. Prof. Andrew Johnson from The University of Nottingham is planning to attend The International Research Symposium on Regulation of Germ Cell Development in vivo and in vitro as a speaker.
    Please contact us for more details.

  6. The goal for international activity support in this innovative area is to advance and promote the research of primates and human reproductive cells.
    Professor Makoto Nagano(McGill University, 7/12-8/3) and Professor Kyle Orwig(Pittsburgh University, 7/23-7/25) will be coming to Japan with this international activity support.
    Both are pioneers in the field of spermatogonial stem cell research.
    They will be holding a lecture at Kyoto University Graduate School of Medicine on 7/24 at 14PM.
    Anyone interested in discussions or cooperative research with the two can contact Takashi Shinohara.


Head investigator:
Prof. Takashi Shinohara

Department of Molecular Genetics, Graduate School of Medicine, Kyoto University.

Yoshida-Konoe-cho,Sakyo-ku, Kyoto 606-8501, Japan

Prof. Masahito Ikawa

Animal Resource Center for Infectious Diseases, Research Institute for Microbial Diseases, Osaka University.

Yamadaoka 3-1, Suita, Osaka 565-0871, Japan